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Ticker
Trade Date
Filing Date
Name
Title
Code
Security
Amount
Price
Value
Trans.
10b5-1
Director
10% Owner
Mcap/AUM
2025-07-03
2025-07-03
SIMON AMY
Chief Medical Officer
S - Sale
Common Stock
-876
$20.12
-17,625.12
1
$1.71B
2025-07-01
2025-07-03
SIMON AMY
Chief Medical Officer
S - Sale
Common Stock
-374
$16.94
-6,336.42
1
$1.71B
2025-04-01
2025-04-03
BELLON CHRISTINE
Chief Legal Officer
S - Sale
Common Stock
-5,674
$18.00
-102K
1
$1.71B
2025-04-01
2025-04-03
CAVANAGH BETHANY
SVP, Finance and Treasurer
S - Sale
Common Stock
-3,015
$18.00
-54,270
1
$1.71B
2025-03-31
2025-04-02
CAVANAGH BETHANY
SVP, Finance and Treasurer
A - Grant
Common Stock
10,000
$0.00
1
$1.71B
2025-01-30
2025-04-02
EVANS JOHN
CEO
M - Exercise
Stock Option (Right to Buy) [F1,F2]
-30,000
$0.00
1
$1.71B
2025-02-18
2025-02-20
CAVANAGH BETHANY
SVP, Finance and Treasurer
S - Sale
Common Stock
-6,287
$35.00
-220K
1
$1.71B
2025-02-14
2025-02-19
BELLON CHRISTINE
Chief Legal Officer
S - Sale
Common Stock
-10,000
$34.00
-340K
1
$1.71B
2025-02-14
2025-02-19
BELLON CHRISTINE
Chief Legal Officer
M - Exercise
Stock Option (Right to Buy)
-10,000
$0.00
2
$1.71B
2025-02-14
2025-02-19
BELLON CHRISTINE
Chief Legal Officer
M - Exercise
Common Stock
10,000
$7.00
70,000
2
$1.71B
2025-01-31
2025-02-03
BELLON CHRISTINE
Chief Legal Officer
A - Grant
Stock Option (Right to Buy)
40,000
$0.00
1
$1.71B
2025-01-31
2025-02-03
CAVANAGH BETHANY
SVP, Finance and Treasurer
A - Grant
Stock Option (Right to Buy)
20,000
$0.00
1
$1.71B
2025-01-31
2025-02-03
CIARAMELLA GIUSEPPE
President
A - Grant
Stock Option (Right to Buy)
70,000
$0.00
1
$1.71B
2025-01-31
2025-02-03
SIMON AMY
Chief Medical Officer
A - Grant
Stock Option (Right to Buy)
55,000
$0.00
1
$1.71B
2025-01-02
2025-01-06
CAVANAGH BETHANY
SVP, Finance and Treasurer
S - Sale
Common Stock
-1,117
$25.00
-27,925
1
$1.71B
2025-01-02
2025-01-06
BELLON CHRISTINE
Chief Legal Officer
S - Sale
Common Stock
-1,241
$25.00
-31,025
1
$1.71B
2024-12-31
2025-01-02
EMANY SRAVAN KUMAR
Chief Financial Officer
A - Grant
Stock Option (Right to Buy)
160K
$0.00
1
$1.71B
2024-12-31
2025-01-02
EMANY SRAVAN KUMAR
Chief Financial Officer
A - Grant
Common Stock
80,000
$0.00
1
$1.71B
2024-12-17
2024-12-19
CIARAMELLA GIUSEPPE
President
M - Exercise
Common Stock
53,500
$1.00
53,500
1
$1.71B
2024-12-17
2024-12-19
CIARAMELLA GIUSEPPE
President
M - Exercise
Stock Option (Right to Buy)
-53,500
$0.00
1
$1.71B
2024-10-14
2024-10-16
CIARAMELLA GIUSEPPE
President
M - Exercise
Stock Option (Right to Buy)
-41,754
$0.00
3
$1.71B
2024-10-14
2024-10-16
CIARAMELLA GIUSEPPE
President
M - Exercise
Common Stock
41,754
$2.00
83,508
3
$1.71B
2024-10-01
2024-10-02
BELLON CHRISTINE
Chief Legal Officer
S - Sale
Common Stock
-385
$23.00
-8,855
1
$1.71B
2024-10-01
2024-10-02
CAVANAGH BETHANY
SVP, Finance and Treasurer
S - Sale
Common Stock
-289
$23.00
-6,647
1
$1.71B
2024-09-30
2024-10-02
CAVANAGH BETHANY
SVP, Finance and Treasurer
A - Grant
Common Stock
2,500
$0.00
1
$1.71B
2024-08-31
2024-09-03
CAVANAGH BETHANY
SVP, Finance and Treasurer
A - Grant
Stock Option (Right to Buy)
5,000
$0.00
1
$1.71B
2024-04-26
2024-04-29
BURRELL TERRY-ANN
Chief Financial Officer
A - Grant
Common Stock
12,500
$0.00
1
$1.71B
2024-04-26
2024-04-29
BURRELL TERRY-ANN
Chief Financial Officer
A - Grant
Stock Option (Right to Buy)
25,000
$0.00
1
$1.71B
2024-04-03
2024-04-03
CIARAMELLA GIUSEPPE
President
A - Grant
Stock Option (Right to Buy)
40,297
$0.00
2
$1.71B
2024-04-01
2024-04-03
BELLON CHRISTINE
Chief Legal Officer
S - Sale
Common Stock
-3,401
$32.00
-109K
1
$1.71B
2024-04-01
2024-04-03
BURRELL TERRY-ANN
Chief Financial Officer
S - Sale
Common Stock
-5,446
$32.00
-174K
1
$1.71B
2024-03-31
2024-04-02
BURRELL TERRY-ANN
Chief Financial Officer
A - Grant
Common Stock
27,500
$0.00
1
$1.71B
2024-01-31
2024-02-02
BELLON CHRISTINE
Chief Legal Officer
A - Grant
Stock Option (Right to Buy)
55,000
$24.00
1.32M
1
$1.71B
2024-01-31
2024-02-02
BURRELL TERRY-ANN
Chief Financial Officer
A - Grant
Stock Option (Right to Buy)
55,000
$24.00
1.32M
1
$1.71B
2024-01-31
2024-02-02
CIARAMELLA GIUSEPPE
President
A - Grant
Stock Option (Right to Buy)
70,000
$24.00
1.68M
1
$1.71B
2024-01-31
2024-02-02
SIMON AMY
Chief Medical Officer
A - Grant
Stock Option (Right to Buy)
55,000
$24.00
1.32M
1
$1.71B
2024-01-03
2024-01-05
BELLON CHRISTINE
Chief Legal Officer
S - Sale
Common Stock
-1,907
$26.00
-49,582
1
$1.71B
2023-11-20
2023-11-22
BELLON CHRISTINE
Chief Legal Officer
M - Exercise
Stock Option (Right to Buy)
-10,000
$0.00
2
$1.71B
2023-11-20
2023-11-22
BELLON CHRISTINE
Chief Legal Officer
M - Exercise
Common Stock
10,000
$7.00
70,000
2
$1.71B
2023-11-20
2023-11-22
BELLON CHRISTINE
Chief Legal Officer
S - Sale
Common Stock
-10,000
$31.00
-310K
2
$1.71B
2023-10-30
2023-11-01
SIMON AMY
Chief Medical Officer
S - Sale
Common Stock
-3,448
$19.00
-65,512
1
$1.71B
2023-10-20
2023-10-24
CIARAMELLA GIUSEPPE
President and CSO
M - Exercise
Stock Option (Right to Buy)
-90,900
$0.00
1
$1.71B
2023-10-20
2023-10-24
CIARAMELLA GIUSEPPE
President and CSO
M - Exercise
Common Stock
90,900
$1.00
90,900
1
$1.71B
2023-10-02
2023-10-04
BELLON CHRISTINE
Chief Legal Officer
S - Sale
Common Stock
-388
$23.00
-8,924
1
$1.71B
2023-07-24
2023-07-25
CIARAMELLA GIUSEPPE
President and CSO
M - Exercise
Stock Option (Right to Buy)
-1,206
$0.00
1
$1.71B
2023-07-24
2023-07-25
CIARAMELLA GIUSEPPE
President and CSO
M - Exercise
Common Stock
1,206
$7.00
8,442
1
$1.71B
2023-07-24
2023-07-25
CIARAMELLA GIUSEPPE
President and CSO
S - Sale
Common Stock
-1,206
$32.00
-38,592
1
$1.71B
2023-07-21
2023-07-25
CIARAMELLA GIUSEPPE
President and CSO
M - Exercise
Stock Option (Right to Buy)
-91,284
$0.00
2
$1.71B
2023-07-21
2023-07-25
CIARAMELLA GIUSEPPE
President and CSO
M - Exercise
Common Stock
91,284
$7.00
639K
2
$1.71B
2023-07-21
2023-07-25
CIARAMELLA GIUSEPPE
President and CSO
S - Sale
Common Stock
-155K
$32.00
-4.97M
1
$1.71B
2023-01-31
2023-04-19
BURRELL TERRY-ANN
Chief Financial Officer
A - Grant
Stock Option (Right to Buy)
40,000
$0.00
1
$1.71B
2023-04-04
2023-04-05
BELLON CHRISTINE
Chief Legal Officer
S - Sale
Common Stock
-1,161
$29.00
-33,669
1
$1.71B
2023-04-04
2023-04-05
BURRELL TERRY-ANN
Chief Financial Officer
S - Sale
Common Stock
-2,186
$29.00
-63,394
1
$1.71B
2023-04-04
2023-04-05
CIARAMELLA GIUSEPPE
President & CSO
S - Sale
Common Stock
-1,754
$29.00
-50,866
1
$1.71B
2023-04-03
2023-04-05
BELLON CHRISTINE
Chief Legal Officer
S - Sale
Common Stock
-931
$30.00
-27,930
1
$1.71B
2023-04-03
2023-04-05
BURRELL TERRY-ANN
Chief Financial Officer
S - Sale
Common Stock
-2,454
$30.00
-73,620
1
$1.71B
2023-04-03
2023-04-05
CIARAMELLA GIUSEPPE
President & CSO
S - Sale
Common Stock
-1,918
$30.00
-57,540
1
$1.71B
2023-03-31
2023-03-31
BURRELL TERRY-ANN
Chief Financial Officer
A - Grant
Common Stock
20,000
$0.00
1
$1.71B
2023-03-30
2023-03-31
BELLON CHRISTINE
Chief Legal Officer
M - Exercise
Stock Option (Right to Buy)
-8,941
$0.00
2
$1.71B
2023-03-30
2023-03-31
BELLON CHRISTINE
Chief Legal Officer
M - Exercise
Common Stock
8,941
$7.00
62,587
2
$1.71B
2023-01-31
2023-03-31
CIARAMELLA GIUSEPPE
President & CSO
A - Grant
Stock Option (Right to Buy)
40,000
$0.00
1
$1.71B
2023-01-31
2023-03-31
BURRELL TERRY-ANN
Chief Financial Officer
A - Grant
Stock Option (Right to Buy)
20,000
$0.00
1
$1.71B
2023-01-27
2023-01-30
BURRELL TERRY-ANN
Chief Financial Officer
M - Exercise
Common Stock
36,152
$14.00
506K
1
$1.71B
2023-01-27
2023-01-30
BURRELL TERRY-ANN
Chief Financial Officer
M - Exercise
Stock Option (Right to Buy)
-36,152
$0.00
1
$1.71B
2023-01-27
2023-01-30
BURRELL TERRY-ANN
Chief Financial Officer
S - Sale
Common Stock
-36,152
$45.00
-1.63M
1
$1.71B
2023-01-26
2023-01-30
BURRELL TERRY-ANN
Chief Financial Officer
M - Exercise
Common Stock
1,102
$14.00
15,428
1
$1.71B
2023-01-26
2023-01-30
BURRELL TERRY-ANN
Chief Financial Officer
M - Exercise
Stock Option (Right to Buy)
-1,102
$0.00
1
$1.71B
2023-01-26
2023-01-30
BURRELL TERRY-ANN
Chief Financial Officer
S - Sale
Common Stock
-1,102
$45.00
-49,590
1
$1.71B
2023-01-24
2023-01-25
BURRELL TERRY-ANN
Chief Financial Officer
M - Exercise
Common Stock
14,810
$14.00
207K
1
$1.71B
2023-01-24
2023-01-25
BURRELL TERRY-ANN
Chief Financial Officer
M - Exercise
Stock Option (Right to Buy)
-14,810
$0.00
1
$1.71B
2023-01-24
2023-01-25
BURRELL TERRY-ANN
Chief Financial Officer
S - Sale
Common Stock
-14,810
$45.00
-666K
1
$1.71B
2023-01-23
2023-01-25
BURRELL TERRY-ANN
Chief Financial Officer
S - Sale
Common Stock
-5,426
$45.00
-244K
1
$1.71B
2023-01-23
2023-01-25
BURRELL TERRY-ANN
Chief Financial Officer
M - Exercise
Common Stock
5,426
$14.00
75,964
1
$1.71B
2023-01-23
2023-01-25
BURRELL TERRY-ANN
Chief Financial Officer
M - Exercise
Stock Option (Right to Buy)
-5,426
$0.00
1
$1.71B
2023-01-18
2023-01-20
BURRELL TERRY-ANN
Chief Financial Officer
S - Sale
Common Stock
-47,195
$45.00
-2.12M
1
$1.71B
2023-01-18
2023-01-20
BURRELL TERRY-ANN
Chief Financial Officer
M - Exercise
Stock Option (Right to Buy)
-39,886
$0.00
1
$1.71B
2023-01-18
2023-01-20
BURRELL TERRY-ANN
Chief Financial Officer
M - Exercise
Common Stock
39,886
$14.00
558K
1
$1.71B
2023-01-03
2023-01-05
CIARAMELLA GIUSEPPE
President & CSO
S - Sale
Common Stock
-53,729
$37.00
-1.99M
4
$1.71B
2023-01-03
2023-01-05
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Stock Option (Right to Buy)
-53,729
$0.00
3
$1.71B
2023-01-03
2023-01-05
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Common Stock
53,729
$1.00
53,729
3
$1.71B
2022-12-30
2023-01-03
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Stock Option (Right to Buy)
-4,500
$0.00
1
$1.71B
2022-12-30
2023-01-03
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Common Stock
4,500
$1.00
4,500
1
$1.71B
2022-12-12
2022-12-20
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Stock Option (Right to Buy)
-18,211
$0.00
1
$1.71B
2022-12-12
2022-12-14
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Common Stock
26,863
$2.00
53,726
2
$1.71B
2022-12-12
2022-12-14
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Stock Option (Right to Buy)
-26,863
$0.00
2
$1.71B
2022-12-12
2022-12-14
CIARAMELLA GIUSEPPE
President & CSO
S - Sale
Common Stock
-51,015
$43.00
-2.19M
3
$1.71B
2022-03-31
2022-04-04
CIARAMELLA GIUSEPPE
President & CSO
S - Sale
Common Stock
-1,859
$59.00
-110K
1
$1.71B
2022-01-31
2022-02-02
CIARAMELLA GIUSEPPE
President & CSO
A - Grant
Stock Option (Right to Buy)
30,000
$0.00
1
$1.71B
2021-12-29
2021-12-30
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Stock Option (Right to Buy)
-39,700
$0.00
1
$1.71B
2021-12-29
2021-12-30
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Common Stock
39,700
$1.00
39,700
1
$1.71B
2021-12-22
2021-12-23
CIARAMELLA GIUSEPPE
President & CSO
S - Sale
Common Stock
-2,607
$86.00
-224K
3
$1.71B
2021-12-22
2021-12-23
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Stock Option (Right to Buy)
-2,607
$0.00
1
$1.71B
2021-12-22
2021-12-23
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Common Stock
2,607
$7.00
18,249
1
$1.71B
2021-12-21
2021-12-22
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Stock Option (Right to Buy)
-25,104
$0.00
1
$1.71B
2021-12-21
2021-12-22
CIARAMELLA GIUSEPPE
President & CSO
S - Sale
Common Stock
-25,104
$86.00
-2.16M
2
$1.71B
2021-12-21
2021-12-22
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Common Stock
25,104
$7.00
176K
1
$1.71B
2021-12-20
2021-12-22
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Common Stock
4,289
$7.00
30,023
1
$1.71B
2021-12-20
2021-12-22
CIARAMELLA GIUSEPPE
President & CSO
S - Sale
Common Stock
-4,289
$85.00
-365K
1
$1.71B
2021-12-20
2021-12-22
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Stock Option (Right to Buy)
-4,289
$0.00
1
$1.71B
2021-09-17
2021-09-21
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Common Stock
18,012
$1.00
18,012
1
$1.71B
2021-09-17
2021-09-21
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Stock Option (Right to Buy)
-18,012
$0.00
1
$1.71B
2020-02-05
2021-09-21
CIARAMELLA GIUSEPPE
President & CSO
A - Grant
Stock Option (Right to Buy)
40,295
$0.00
2
$1.71B
2021-06-30
2021-07-02
BURRELL TERRY-ANN
CFO
M - Exercise
Stock Option (Right to Buy)
-30,000
$0.00
1
$1.71B
2021-06-28
2021-06-30
CIARAMELLA GIUSEPPE
President & CSO
S - Sale
Common Stock
-78,580
$107.00
-8.41M
8
$1.71B
2021-06-28
2021-06-30
EVANS JOHN
Chief Executive Officer
L - Small Acquisition
Common Stock
32
$0.00
1
$1.71B
2021-06-28
2021-06-30
BURRELL TERRY-ANN
CFO
M - Exercise
Stock Option (Right to Buy)
-45,000
$0.00
1
$1.71B
2021-06-28
2021-06-30
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Stock Option (Right to Buy)
-78,580
$0.00
1
$1.71B
2021-06-28
2021-06-30
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Common Stock
78,580
$17.00
1.34M
1
$1.71B
2021-06-25
2021-06-30
EVANS JOHN
Chief Executive Officer
L - Small Acquisition
Common Stock
32
$0.00
1
$1.71B
2021-03-31
2021-04-12
EVANS JOHN
Chief Executive Officer
L - Small Acquisition
Common Stock
32
$0.00
1
$1.71B
2021-03-22
2021-04-12
EVANS JOHN
Chief Executive Officer
L - Small Acquisition
Common Stock
32
$0.00
1
$1.71B
2021-03-18
2021-04-12
EVANS JOHN
Chief Executive Officer
L - Small Acquisition
Common Stock
33
$0.00
1
$1.71B
2021-03-31
2021-04-02
CIARAMELLA GIUSEPPE
President & CSO
A - Grant
Stock Option (Right to Buy)
50,000
$0.00
1
$1.71B
2021-03-05
2021-04-02
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Common Stock
4,030
$1.00
4,030
1
$1.71B
2021-03-05
2021-04-02
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Stock Option (Right to Buy)
-4,030
$0.00
1
$1.71B
2021-01-04
2021-01-05
BURRELL TERRY-ANN
CFO
M - Exercise
Stock Option (Right to Buy)
-25,000
$0.00
1
$1.71B
2020-12-30
2021-01-04
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Stock Option (Right to Buy)
-55,842
$0.00
2
$1.71B
2020-12-30
2021-01-04
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Common Stock
55,842
$1.00
55,842
2
$1.71B
2020-12-30
2021-01-04
CIARAMELLA GIUSEPPE
President & CSO
S - Sale
Common Stock
-43,842
$83.00
-3.64M
11
$1.71B
2020-09-30
2020-10-02
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Stock Option (Right to Buy)
-3,731
$0.00
1
$1.71B
2020-09-30
2020-10-02
CIARAMELLA GIUSEPPE
President & CSO
M - Exercise
Common Stock
3,731
$1.00
3,731
1
$1.71B
2020-09-18
2020-09-21
BURRELL TERRY-ANN
CFO
M - Exercise
Stock Option (Right to Buy)
-7,309
$0.00
1
$1.71B
2020-02-10
2020-02-11
CIARAMELLA GIUSEPPE
President & CSO
A - Grant
Stock Option (Right to Buy)
511K
$0.00
1
$1.71B
2020-02-10
2020-02-11
ARCH VENTURE PARTNERS IX, LLC
C - Conversion
Series A-1 Preferred Stock
-2.68M
2
$1.71B
2020-02-10
2020-02-11
ARCH VENTURE PARTNERS IX, LLC
C - Conversion
Series A-2 Preferred Stock
-5.50M
2
$1.71B
2020-02-10
2020-02-11
ARCH VENTURE PARTNERS IX, LLC
C - Conversion
Series B Preferred Stock
-66,368
2
$1.71B
2020-02-10
2020-02-11
REDMILE GROUP, LLC
C - Conversion
Series B Redeemable Convertible Preferred Stock
-5.21M
$0.00
1
$1.71B