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Trade Date
Filing Date
Name
Title
Code
Security
Amount
Price
Value
Trans.
Director
10% Owner
Mcap/AUM
2025-03-21
2025-03-24
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-18,881
$30.00
-566K
1
$929.23M
2025-03-21
2025-03-24
TUPPER COLLEEN
EVP & Chief Financial Officer
S - Sale
Common Stock
-6,396
$30.00
-192K
1
$929.23M
2025-03-20
2025-03-24
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-1,927
$30.00
-57,810
1
$929.23M
2025-03-20
2025-03-24
TUPPER COLLEEN
EVP & Chief Financial Officer
S - Sale
Common Stock
-1,206
$30.00
-36,180
1
$929.23M
2025-03-14
2025-03-18
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-2,255
$30.00
-67,650
1
$929.23M
2025-03-14
2025-03-18
TUPPER COLLEEN
EVP & Chief Financial Officer
S - Sale
Common Stock
-977
$30.00
-29,310
1
$929.23M
2025-03-11
2025-03-18
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-15,387
$30.00
-462K
1
$929.23M
2025-03-11
2025-03-13
TUPPER COLLEEN
EVP & Chief Financial Officer
S - Sale
Common Stock
-10,445
$30.00
-313K
1
$929.23M
2025-03-06
2025-03-13
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-15,387
$30.00
-462K
1
$929.23M
2025-03-07
2025-03-10
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-2,348
$30.00
-70,440
1
$929.23M
2025-03-07
2025-03-10
TUPPER COLLEEN
EVP & Chief Financial Officer
S - Sale
Common Stock
-1,504
$30.00
-45,120
1
$929.23M
2025-03-06
2025-03-10
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-3,295
$30.00
-98,850
1
$929.23M
2025-03-06
2025-03-10
TUPPER COLLEEN
EVP & Chief Financial Officer
S - Sale
Common Stock
-1,949
$30.00
-58,470
1
$929.23M
2025-03-06
2025-03-06
KUHLMANN SHIRLEY
EVP and General Counsel
S - Sale
Common Stock
-26,067
$29.00
-756K
1
$929.23M
2025-03-05
2025-03-06
KUHLMANN SHIRLEY
EVP and General Counsel
S - Sale
Common Stock
-20,000
$28.00
-560K
1
$929.23M
2025-03-04
2025-03-06
KUHLMANN SHIRLEY
EVP and General Counsel
M - Exercise
Common Stock
40,000
$24.00
960K
1
$929.23M
2025-03-04
2025-03-06
KUHLMANN SHIRLEY
EVP and General Counsel
S - Sale
Common Stock
-40,000
$28.00
-1.12M
1
$929.23M
2025-03-04
2025-03-06
KUHLMANN SHIRLEY
EVP and General Counsel
M - Exercise
Stock Option (Right to Purchase)
-40,000
$0.00
1
$929.23M
2025-02-10
2025-02-12
DREYER SCOTT
EVP & Chief Commercial Officer
A - Grant
Common Stock
71,427
$0.00
2
$929.23M
2025-02-10
2025-02-12
KUHLMANN SHIRLEY
EVP and General Counsel
A - Grant
Common Stock
69,995
$0.00
2
$929.23M
2025-02-10
2025-02-12
SMITH THOMAS
EVP and Chief Medical Officer
A - Grant
Common Stock
39,075
$0.00
2
$929.23M
2025-02-10
2025-02-12
TUPPER COLLEEN
EVP & Chief Financial Officer
A - Grant
Common Stock
78,725
$0.00
2
$929.23M
2025-02-10
2025-02-12
DREYER SCOTT
EVP & Chief Commercial Officer
F - Tax
Common Stock
-29,623
$31.00
-918K
2
$929.23M
2025-02-10
2025-02-12
KUHLMANN SHIRLEY
EVP and General Counsel
F - Tax
Common Stock
-34,975
$31.00
-1.08M
2
$929.23M
2025-02-10
2025-02-12
SMITH THOMAS
EVP and Chief Medical Officer
F - Tax
Common Stock
-5,897
$31.00
-183K
2
$929.23M
2025-02-10
2025-02-12
TUPPER COLLEEN
EVP & Chief Financial Officer
F - Tax
Common Stock
-30,426
$31.00
-943K
2
$929.23M
2025-01-10
2025-01-14
KUHLMANN SHIRLEY
EVP and General Counsel
M - Exercise
Stock Option (Right to Purchase)
-27,500
$0.00
1
$929.23M
2025-01-10
2025-01-14
KUHLMANN SHIRLEY
EVP and General Counsel
M - Exercise
Common Stock
27,500
$21.00
578K
1
$929.23M
2025-01-10
2025-01-14
KUHLMANN SHIRLEY
EVP and General Counsel
S - Sale
Common Stock
-27,500
$33.00
-908K
2
$929.23M
2024-11-12
2024-11-14
KARNANI VIKRAM
President and CEO
A - Grant
Stock Option (Right to Purchase)
130K
$0.00
1
$929.23M
2024-09-13
2024-09-17
SMITH THOMAS
EVP and Chief Medical Officer
S - Sale
Common Stock
-9,593
$37.00
-355K
1
$929.23M
2024-09-06
2024-09-06
KUHLMANN SHIRLEY
EVP and General Counsel
S - Sale
Common Stock
-977
$37.00
-36,149
1
$929.23M
2024-09-05
2024-09-06
KUHLMANN SHIRLEY
EVP and General Counsel
S - Sale
Common Stock
-19,248
$38.00
-731K
2
$929.23M
2024-06-03
2024-06-05
KUHLMANN SHIRLEY
EVP and General Counsel
S - Sale
Common Stock
-25,000
$33.00
-825K
2
$929.23M
2024-05-28
2024-05-29
TUPPER COLLEEN
EVP & Chief Financial Officer
S - Sale
Common Stock
-19,710
$34.00
-670K
1
$929.23M
2024-05-24
2024-05-28
DREYER SCOTT
EVP & Chief Commercial Officer
M - Exercise
Stock Option (Right to Purchase)
-23,791
$0.00
1
$929.23M
2024-05-24
2024-05-28
DREYER SCOTT
EVP & Chief Commercial Officer
M - Exercise
Common Stock
23,791
$24.00
571K
1
$929.23M
2024-05-24
2024-05-28
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-56,807
$34.00
-1.93M
1
$929.23M
2024-05-23
2024-05-28
DREYER SCOTT
EVP & Chief Commercial Officer
M - Exercise
Common Stock
51,209
$24.00
1.23M
1
$929.23M
2024-05-23
2024-05-28
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-51,209
$34.00
-1.74M
1
$929.23M
2024-05-23
2024-05-28
DREYER SCOTT
EVP & Chief Commercial Officer
M - Exercise
Stock Option (Right to Purchase)
-51,209
$0.00
1
$929.23M
2024-05-14
2024-05-16
BOHLIN GAREN
M - Exercise
Stock Option (Right to Purchase)
-28,985
$0.00
1
$929.23M
2024-02-29
2024-03-04
SMITH THOMAS
EVP and Chief Medical Officer
S - Sale
Common Stock
-995
$37.00
-36,815
1
$929.23M
2024-02-26
2024-02-28
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-10,000
$36.00
-360K
2
$929.23M
2024-02-12
2024-02-14
SMITH THOMAS
EVP and Chief Medical Officer
A - Grant
Common Stock
35,423
$0.00
2
$929.23M
2024-02-12
2024-02-14
TUPPER COLLEEN
EVP & Chief Financial Officer
A - Grant
Common Stock
71,456
$0.00
2
$929.23M
2024-02-12
2024-02-14
CIAFFONI JOSEPH
President and CEO
F - Tax
Common Stock
-129K
$34.00
-4.38M
2
$929.23M
2024-02-12
2024-02-14
DREYER SCOTT
EVP & Chief Commercial Officer
F - Tax
Common Stock
-29,690
$34.00
-1.01M
2
$929.23M
2024-02-12
2024-02-14
KUHLMANN SHIRLEY
EVP and General Counsel
F - Tax
Common Stock
-31,756
$34.00
-1.08M
2
$929.23M
2024-02-12
2024-02-14
SMITH THOMAS
EVP and Chief Medical Officer
F - Tax
Common Stock
-3,199
$34.00
-109K
2
$929.23M
2024-02-12
2024-02-14
TUPPER COLLEEN
EVP & Chief Financial Officer
F - Tax
Common Stock
-26,321
$34.00
-895K
2
$929.23M
2024-02-12
2024-02-14
DREYER SCOTT
EVP & Chief Commercial Officer
A - Grant
Common Stock
67,286
$0.00
2
$929.23M
2024-02-12
2024-02-14
KUHLMANN SHIRLEY
EVP and General Counsel
A - Grant
Common Stock
76,647
$0.00
2
$929.23M
2024-01-16
2024-01-18
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-23,560
$32.00
-754K
1
$929.23M
2023-12-21
2023-12-22
CIAFFONI JOSEPH
President and CEO
M - Exercise
Common Stock
4,357
$21.00
91,497
1
$929.23M
2023-12-21
2023-12-22
CIAFFONI JOSEPH
President and CEO
M - Exercise
Stock Option (Right to Purchase)
-4,357
$0.00
1
$929.23M
2023-12-21
2023-12-22
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-4,357
$30.00
-131K
1
$929.23M
2023-12-20
2023-12-20
CIAFFONI JOSEPH
President and CEO
M - Exercise
Stock Option (Right to Purchase)
-26,454
$0.00
1
$929.23M
2023-12-20
2023-12-20
CIAFFONI JOSEPH
President and CEO
M - Exercise
Common Stock
26,454
$21.00
556K
1
$929.23M
2023-12-20
2023-12-20
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-26,454
$30.00
-794K
1
$929.23M
2023-12-19
2023-12-20
CIAFFONI JOSEPH
President and CEO
M - Exercise
Stock Option (Right to Purchase)
-14,516
$0.00
1
$929.23M
2023-12-19
2023-12-20
CIAFFONI JOSEPH
President and CEO
M - Exercise
Common Stock
14,516
$21.00
305K
1
$929.23M
2023-12-19
2023-12-20
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-14,516
$30.00
-435K
1
$929.23M
2023-12-18
2023-12-20
CIAFFONI JOSEPH
President and CEO
M - Exercise
Common Stock
27,798
$21.00
584K
1
$929.23M
2023-12-18
2023-12-20
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-27,798
$30.00
-834K
1
$929.23M
2023-12-18
2023-12-20
CIAFFONI JOSEPH
President and CEO
M - Exercise
Stock Option (Right to Purchase)
-27,798
$0.00
1
$929.23M
2023-11-27
2023-11-29
KUHLMANN SHIRLEY
EVP and General Counsel
M - Exercise
Common Stock
25,600
$16.00
410K
1
$929.23M
2023-11-27
2023-11-29
KUHLMANN SHIRLEY
EVP and General Counsel
S - Sale
Common Stock
-25,600
$26.00
-666K
1
$929.23M
2023-11-27
2023-11-29
KUHLMANN SHIRLEY
EVP and General Counsel
M - Exercise
Stock Option (Right to Purchase)
-25,600
$0.00
1
$929.23M
2023-06-26
2023-06-28
KUHLMANN SHIRLEY
EVP and General Counsel
S - Sale
Common Stock
-17,984
$22.00
-396K
2
$929.23M
2023-06-02
2023-06-02
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-31,272
$22.00
-688K
2
$929.23M
2023-06-01
2023-06-02
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-31,272
$22.00
-688K
1
$929.23M
2023-05-31
2023-06-01
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-31,272
$22.00
-688K
1
$929.23M
2023-05-30
2023-06-01
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-31,271
$22.00
-688K
1
$929.23M
2023-03-15
2023-03-17
TUPPER COLLEEN
EVP & Chief Financial Officer
S - Sale
Common Stock
-31,640
$24.00
-759K
1
$929.23M
2023-03-01
2023-03-03
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-13,324
$27.00
-360K
1
$929.23M
2023-02-13
2023-02-14
CIAFFONI JOSEPH
President and CEO
M - Exercise
Stock Option (Right to Purchase)
-11,250
$0.00
1
$929.23M
2023-02-13
2023-02-14
CIAFFONI JOSEPH
President and CEO
M - Exercise
Common Stock
11,250
$16.00
180K
1
$929.23M
2023-02-13
2023-02-14
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-11,250
$27.00
-304K
1
$929.23M
2023-02-13
2023-02-14
KUHLMANN SHIRLEY
EVP and General Counsel
S - Sale
Common Stock
-21,811
$27.00
-589K
1
$929.23M
2023-02-10
2023-02-14
CIAFFONI JOSEPH
President and CEO
F - Tax
Common Stock
-104K
$27.00
-2.80M
2
$929.23M
2023-02-10
2023-02-14
KUHLMANN SHIRLEY
EVP and General Counsel
F - Tax
Common Stock
-24,046
$27.00
-649K
2
$929.23M
2023-02-10
2023-02-14
TUPPER COLLEEN
EVP & Chief Financial Officer
F - Tax
Common Stock
-10,854
$27.00
-293K
2
$929.23M
2023-02-10
2023-02-14
DREYER SCOTT
EVP & Chief Commercial Officer
F - Tax
Common Stock
-21,326
$27.00
-576K
2
$929.23M
2023-02-10
2023-02-14
DREYER SCOTT
EVP & Chief Commercial Officer
A - Grant
Common Stock
66,734
$0.00
2
$929.23M
2023-02-10
2023-02-14
KUHLMANN SHIRLEY
EVP and General Counsel
A - Grant
Common Stock
73,864
$0.00
2
$929.23M
2023-02-10
2023-02-14
SMITH THOMAS
EVP and Chief Medical Officer
A - Grant
Common Stock
31,185
$0.00
1
$929.23M
2023-02-10
2023-02-14
TUPPER COLLEEN
EVP & Chief Financial Officer
A - Grant
Common Stock
57,610
$0.00
2
$929.23M
2023-01-09
2023-01-11
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-17,834
$27.00
-482K
3
$929.23M
2022-12-27
2022-12-27
HEFFERNAN MICHAEL THOMAS
M - Exercise
Stock Option (Right to Purchase)
-19,815
$0.00
2
$929.23M
2022-12-27
2022-12-27
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-2,204
$24.00
-52,896
2
$929.23M
2022-12-23
2022-12-27
HEFFERNAN MICHAEL THOMAS
M - Exercise
Stock Option (Right to Purchase)
-4,989
$0.00
1
$929.23M
2022-12-23
2022-12-27
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-147
$23.00
-3,381
1
$929.23M
2022-12-22
2022-12-27
HEFFERNAN MICHAEL THOMAS
M - Exercise
Stock Option (Right to Purchase)
-237
$0.00
1
$929.23M
2022-12-22
2022-12-27
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-110
$23.00
-2,530
1
$929.23M
2022-12-21
2022-12-21
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-7,333
$23.00
-169K
1
$929.23M
2022-12-21
2022-12-21
HEFFERNAN MICHAEL THOMAS
M - Exercise
Stock Option (Right to Purchase)
-46,600
$0.00
1
$929.23M
2022-12-20
2022-12-21
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-9,375
$23.00
-216K
1
$929.23M
2022-12-20
2022-12-21
HEFFERNAN MICHAEL THOMAS
M - Exercise
Stock Option (Right to Purchase)
-33,758
$0.00
1
$929.23M
2022-12-19
2022-12-21
HEFFERNAN MICHAEL THOMAS
M - Exercise
Stock Option (Right to Purchase)
-3,606
$0.00
1
$929.23M
2022-12-19
2022-12-21
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-1,134
$23.00
-26,082
1
$929.23M
2022-12-13
2022-12-14
HEFFERNAN MICHAEL THOMAS
M - Exercise
Stock Option (Right to Purchase)
-162K
$0.00
3
$929.23M
2022-12-12
2022-12-14
HEFFERNAN MICHAEL THOMAS
M - Exercise
Stock Option (Right to Purchase)
-12,179
$0.00
2
$929.23M
2022-12-12
2022-12-14
HEFFERNAN MICHAEL THOMAS
M - Exercise
Stock Option (Right to Purchase)t to
-15,741
$0.00
1
$929.23M
2022-12-02
2022-12-05
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-54,400
$23.00
-1.25M
1
$929.23M
2022-12-01
2022-12-05
CIAFFONI JOSEPH
President and CEO
M - Exercise
Common Stock
76,653
$16.00
1.23M
1
$929.23M
2022-12-01
2022-12-05
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-76,653
$22.00
-1.69M
1
$929.23M
2022-12-01
2022-12-05
CIAFFONI JOSEPH
President and CEO
M - Exercise
Stock Option (Right to Purchase)
-76,653
$0.00
1
$929.23M
2022-11-28
2022-11-30
CIAFFONI JOSEPH
President and CEO
M - Exercise
Stock Option (Right to Purchase)
-43
$0.00
1
$929.23M
2022-11-28
2022-11-30
CIAFFONI JOSEPH
President and CEO
M - Exercise
Common Stock
43
$16.00
688
1
$929.23M
2022-11-22
2022-11-25
CIAFFONI JOSEPH
President and CEO
M - Exercise
Stock Option (Right to Purchase)
-65
$0.00
1
$929.23M
2022-11-22
2022-11-25
CIAFFONI JOSEPH
President and CEO
M - Exercise
Common Stock
65
$16.00
1,040
1
$929.23M
2022-11-22
2022-11-25
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-65
$22.00
-1,430
1
$929.23M
2022-11-18
2022-11-22
CIAFFONI JOSEPH
President and CEO
M - Exercise
Common Stock
1,989
$16.00
31,824
1
$929.23M
2022-11-18
2022-11-22
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-1,989
$22.00
-43,758
1
$929.23M
2022-11-18
2022-11-22
CIAFFONI JOSEPH
President and CEO
M - Exercise
Stock Option (Right to Purchase)
-1,989
$0.00
1
$929.23M
2022-10-04
2022-10-06
TUPPER COLLEEN
EVP & Chief Financial Officer
S - Sale
Common Stock
-4,350
$17.00
-73,950
1
$929.23M
2022-09-15
2022-09-16
KUHLMANN SHIRLEY
EVP and General Counsel
S - Sale
Common Stock
-38,589
$18.00
-695K
1
$929.23M
2022-08-11
2022-08-15
KUHLMANN SHIRLEY
EVP and General Counsel
S - Sale
Common Stock
-300
$20.00
-6,000
1
$929.23M
2022-07-11
2022-07-13
DREYER SCOTT
EVP & Chief Commercial Officer
F - Tax
Common Stock
-594
$17.00
-10,098
1
$929.23M
2022-07-01
2022-07-06
CIAFFONI JOSEPH
President and CEO
F - Tax
Common Stock
-1,394
$18.00
-25,092
1
$929.23M
2022-03-16
2022-03-18
KUHLMANN SHIRLEY
EVP and General Counsel
F - Tax
Common Stock
-734
$19.00
-13,946
1
$929.23M
2022-03-01
2022-03-03
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-76,094
$18.00
-1.37M
2
$929.23M
2022-02-10
2022-03-03
TUPPER COLLEEN
EVP & Chief Financial Officer
A - Grant
Common Stock
56,712
$0.00
2
$929.23M
2022-02-10
2022-03-03
TUPPER COLLEEN
EVP & Chief Financial Officer
F - Tax
Common Stock
-4,058
$18.00
-73,044
2
$929.23M
2022-02-18
2022-02-28
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-10,559
$22.00
-232K
1
$929.23M
2022-02-10
2022-02-14
DREYER SCOTT
EVP & Chief Commercial Officer
A - Grant
Common Stock
66,175
$0.00
2
$929.23M
2022-02-10
2022-02-14
KUHLMANN SHIRLEY
EVP and General Counsel
A - Grant
Common Stock
71,041
$0.00
2
$929.23M
2022-02-10
2022-02-14
MALAMUT RICHARD
EVP and Chief Medical Officer
A - Grant
Common Stock
43,006
$0.00
2
$929.23M
2022-02-10
2022-02-14
TUPPER COLLEEN
EVP & Chief Financial Officer
A - Grant
Common Stock
49,712
$0.00
2
$929.23M
2022-02-10
2022-02-14
CIAFFONI JOSEPH
President and CEO
F - Tax
Common Stock
-52,997
$18.00
-954K
2
$929.23M
2022-02-10
2022-02-14
DREYER SCOTT
EVP & Chief Commercial Officer
F - Tax
Common Stock
-10,659
$18.00
-192K
2
$929.23M
2022-02-10
2022-02-14
KUHLMANN SHIRLEY
EVP and General Counsel
F - Tax
Common Stock
-11,179
$18.00
-201K
2
$929.23M
2022-02-10
2022-02-14
MALAMUT RICHARD
EVP and Chief Medical Officer
F - Tax
Common Stock
-6,300
$18.00
-113K
2
$929.23M
2022-02-10
2022-02-14
TUPPER COLLEEN
EVP & Chief Financial Officer
F - Tax
Common Stock
-4,058
$18.00
-73,044
2
$929.23M
2022-01-10
2022-01-12
DREYER SCOTT
EVP & Chief Commercial Officer
F - Tax
Common Stock
-701
$19.00
-13,319
1
$929.23M
2022-01-03
2022-01-05
CIAFFONI JOSEPH
President and CEO
F - Tax
Common Stock
-1,090
$19.00
-20,710
1
$929.23M
2021-12-15
2021-12-17
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-5,693
$18.00
-102K
1
$929.23M
2021-09-16
2021-09-20
KUHLMANN SHIRLEY
EVP and General Counsel
F - Tax
Common Stock
-734
$20.00
-14,680
1
$929.23M
2021-08-10
2021-08-12
CIAFFONI JOSEPH
President and CEO
F - Tax
Common Stock
-1,386
$19.00
-26,334
1
$929.23M
2021-08-10
2021-08-12
FLEMING ALISON
EVP & Chief Technical Officer
F - Tax
Common Stock
-1,386
$19.00
-26,334
1
$929.23M
2021-07-12
2021-07-14
DREYER SCOTT
EVP & Chief Commercial Officer
F - Tax
Common Stock
-595
$23.00
-13,685
1
$929.23M
2021-07-01
2021-07-06
CIAFFONI JOSEPH
President and CEO
F - Tax
Common Stock
-1,394
$24.00
-33,456
1
$929.23M
2021-06-02
2021-06-03
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-5,861
$23.00
-135K
1
$929.23M
2021-06-01
2021-06-03
CIAFFONI JOSEPH
President and CEO
M - Exercise
Common Stock
16,205
$8.00
130K
1
$929.23M
2021-06-01
2021-06-03
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-16,205
$23.00
-373K
2
$929.23M
2021-06-01
2021-06-03
CIAFFONI JOSEPH
President and CEO
M - Exercise
Stock Option (Right to Purchase)
-16,205
$0.00
1
$929.23M
2021-06-01
2021-06-03
CIAFFONI JOSEPH
President and CEO
F - Tax
Common Stock
-4,672
$23.00
-107K
1
$929.23M
2021-05-24
2021-05-24
TUPPER COLLEEN
EVP & Chief Financial Officer
A - Grant
Common Stock
42,000
$0.00
1
$929.23M
2021-05-10
2021-05-12
KUHLMANN SHIRLEY
EVP and General Counsel
S - Sale
Common Stock
-7,000
$23.00
-161K
1
$929.23M
2021-04-01
2021-04-05
FLEMING ALISON
EVP & Chief Technical Officer
F - Tax
Common Stock
-9,657
$23.00
-222K
2
$929.23M
2021-04-01
2021-04-05
MALAMUT RICHARD
EVP and Chief Medical Officer
F - Tax
Common Stock
-3,119
$23.00
-71,737
1
$929.23M
2021-03-16
2021-03-18
KUHLMANN SHIRLEY
EVP and General Counsel
F - Tax
Common Stock
-734
$25.00
-18,350
1
$929.23M
2021-03-01
2021-03-03
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-64,768
$23.00
-1.49M
2
$929.23M
2021-03-01
2021-03-03
CIAFFONI JOSEPH
President and CEO
M - Exercise
Stock Option (Right to Purchase)
-48,616
$0.00
1
$929.23M
2021-03-01
2021-03-03
CIAFFONI JOSEPH
President and CEO
M - Exercise
Common Stock
48,616
$8.00
389K
1
$929.23M
2021-03-01
2021-03-03
FLEMING ALISON
Chief Technical Officer
S - Sale
Common Stock
-6,011
$23.00
-138K
1
$929.23M
2018-05-10
2021-03-03
FLEMING ALISON
Chief Technical Officer
S - Sale
Common Stock
-1,400
$27.00
-37,800
1
$929.23M
2018-01-19
2021-03-03
FLEMING ALISON
Chief Technical Officer
S - Sale
Common Stock
-3,324
$23.00
-76,452
3
$929.23M
2018-01-19
2021-03-03
FLEMING ALISON
Chief Technical Officer
M - Exercise
Common Stock
3,324
$2.00
6,648
3
$929.23M
2018-01-19
2021-03-03
FLEMING ALISON
Chief Technical Officer
M - Exercise
Stock Option (Right to Purchase)
-3,324
$0.00
3
$929.23M
2018-01-12
2021-03-03
FLEMING ALISON
Chief Technical Officer
M - Exercise
Common Stock
7,500
$1.00
7,500
2
$929.23M
2018-01-12
2021-03-03
FLEMING ALISON
Chief Technical Officer
M - Exercise
Stock Option (Right to Purchase)
-7,500
$0.00
2
$929.23M
2018-01-12
2021-03-03
FLEMING ALISON
Chief Technical Officer
S - Sale
Common Stock
-7,500
$21.00
-158K
2
$929.23M
2021-02-11
2021-02-12
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-7,898
$25.00
-197K
2
$929.23M
2021-02-10
2021-02-12
CIAFFONI JOSEPH
President and CEO
F - Tax
Common Stock
-23,786
$26.00
-618K
2
$929.23M
2021-02-10
2021-02-12
DREYER SCOTT
EVP & Chief Commercial Officer
F - Tax
Common Stock
-5,184
$26.00
-135K
2
$929.23M
2021-02-10
2021-02-12
FLEMING ALISON
Chief Technical Officer
F - Tax
Common Stock
-7,144
$26.00
-186K
2
$929.23M
2021-02-10
2021-02-12
KUHLMANN SHIRLEY
EVP and General Counsel
F - Tax
Common Stock
-5,858
$26.00
-152K
2
$929.23M
2021-02-10
2021-02-12
MALAMUT RICHARD
EVP and Chief Medical Officer
F - Tax
Common Stock
-2,300
$26.00
-59,800
2
$929.23M
2021-02-10
2021-02-12
BRANNELLY PAUL
Executive Vice President & CFO
F - Tax
Common Stock
-8,491
$26.00
-221K
2
$929.23M
2021-01-20
2021-01-22
KUHLMANN SHIRLEY
EVP and General Counsel
S - Sale
Common Stock
-6,081
$24.00
-146K
1
$929.23M
2021-01-19
2021-01-22
KUHLMANN SHIRLEY
EVP and General Counsel
A - Grant
Common Stock
52,132
$0.00
2
$929.23M
2021-01-19
2021-01-22
DREYER SCOTT
EVP & Chief Commercial Officer
A - Grant
Common Stock
51,945
$0.00
2
$929.23M
2021-01-19
2021-01-22
FLEMING ALISON
Chief Technology Officer
A - Grant
Common Stock
51,889
$0.00
2
$929.23M
2021-01-19
2021-01-22
BRANNELLY PAUL
Executive Vice President & CFO
A - Grant
Common Stock
50,161
$0.00
2
$929.23M
2021-01-19
2021-01-22
MALAMUT RICHARD
EVP and Chief Medical Officer
A - Grant
Common Stock
39,147
$0.00
2
$929.23M
2021-01-20
2021-01-21
KUHLMANN SHIRLEY
EVP and General Counsel
S - Sale
Common Stock
-6,081
$24.00
-146K
1
$929.23M
2021-01-19
2021-01-21
FLEMING ALISON
Chief Technology Officer
A - Grant
Common Stock
51,889
$0.00
2
$929.23M
2021-01-19
2021-01-21
BRANNELLY PAUL
Executive Vice President & CFO
A - Grant
Stock Option (Right to Purchase)
120K
$0.00
1
$929.23M
2021-01-19
2021-01-21
BRANNELLY PAUL
Executive Vice President & CFO
A - Grant
Common Stock
50,161
$0.00
2
$929.23M
2021-01-19
2021-01-21
CIAFFONI JOSEPH
President and CEO
A - Grant
Stock Option (Right to Purchase)
420K
$0.00
1
$929.23M
2021-01-19
2021-01-21
DREYER SCOTT
EVP & Chief Commercial Officer
A - Grant
Stock Option (Right to Purchase)
131K
$0.00
1
$929.23M
2021-01-19
2021-01-21
DREYER SCOTT
EVP & Chief Commercial Officer
A - Grant
Common Stock
51,945
$0.00
2
$929.23M
2021-01-19
2021-01-21
FLEMING ALISON
Chief Technology Officer
A - Grant
Stock Option (Right to Purchase)
130K
$0.00
1
$929.23M
2021-01-19
2021-01-21
KUHLMANN SHIRLEY
EVP and General Counsel
A - Grant
Stock Option (Right to Purchase)
130K
$0.00
1
$929.23M
2021-01-19
2021-01-21
KUHLMANN SHIRLEY
EVP and General Counsel
A - Grant
Common Stock
52,132
$0.00
2
$929.23M
2021-01-19
2021-01-21
MALAMUT RICHARD
EVP and Chief Medical Officer
A - Grant
Stock Option (Right to Purchase)
106K
$0.00
1
$929.23M
2021-01-19
2021-01-21
MALAMUT RICHARD
EVP and Chief Medical Officer
A - Grant
Common Stock
39,147
$0.00
2
$929.23M
2021-01-15
2021-01-20
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-1,322
$23.00
-30,406
1
$929.23M
2021-01-11
2021-01-13
DREYER SCOTT
EVP & Chief Commercial Officer
F - Tax
Common Stock
-701
$21.00
-14,721
1
$929.23M
2021-01-07
2021-01-11
FLEMING ALISON
Chief Technology Officer
S - Sale
Common Stock
-16,042
$22.00
-353K
1
$929.23M
2021-01-07
2021-01-11
FLEMING ALISON
Chief Technology Officer
M - Exercise
Stock Option (Right to Purchase)
-16,042
$0.00
1
$929.23M
2021-01-07
2021-01-11
FLEMING ALISON
Chief Technology Officer
M - Exercise
Common Stock
16,042
$6.00
96,252
1
$929.23M
2018-01-19
2021-01-11
FLEMING ALISON
Chief Technology Officer
M - Exercise
Common Stock
3,336
$6.00
20,016
1
$929.23M
2018-01-19
2021-01-11
FLEMING ALISON
Chief Technology Officer
S - Sale
Common Stock
-3,336
$23.00
-76,728
1
$929.23M
2018-01-19
2021-01-11
FLEMING ALISON
Chief Technology Officer
M - Exercise
Stock Option (Right to Purchase)
-3,336
$0.00
1
$929.23M
2021-01-04
2021-01-06
CIAFFONI JOSEPH
President and CEO
F - Tax
Common Stock
-1,090
$20.00
-21,800
1
$929.23M
2020-12-03
2020-12-07
FLEMING ALISON
Chief Technology Officer
S - Sale
Common Stock
-5,967
$19.00
-113K
1
$929.23M
2020-11-30
2020-12-02
CIAFFONI JOSEPH
President and CEO
F - Tax
Common Stock
-4,672
$18.00
-84,096
1
$929.23M
2020-11-18
2020-11-20
FLEMING ALISON
Chief Technology Officer
M - Exercise
Stock Option (Right to Purchase)
-16,000
$0.00
1
$929.23M
2020-11-18
2020-11-20
FLEMING ALISON
Chief Technology Officer
M - Exercise
Common Stock
16,000
$6.00
96,000
1
$929.23M
2020-10-15
2020-10-16
KUHLMANN SHIRLEY
EVP and General Counsel
S - Sale
Common Stock
-7,060
$21.00
-148K
1
$929.23M
2020-09-24
2020-09-28
BALICE-GORDON RITA
A - Grant
Stock Option (Right to Purchase)
10,055
$0.00
1
$929.23M
2020-09-16
2020-09-18
KUHLMANN SHIRLEY
EVP and General Counsel
F - Tax
Common Stock
-734
$19.00
-13,946
1
$929.23M
2020-08-10
2020-08-12
BRANNELLY PAUL
Executive Vice President & CFO
F - Tax
Common Stock
-1,515
$19.00
-28,785
1
$929.23M
2020-08-10
2020-08-12
CIAFFONI JOSEPH
President and CEO
F - Tax
Common Stock
-1,386
$19.00
-26,334
1
$929.23M
2020-08-10
2020-08-12
FLEMING ALISON
Chief Technology Officer
F - Tax
Common Stock
-1,515
$19.00
-28,785
1
$929.23M
2020-07-13
2020-07-14
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-1,429
$17.00
-24,293
1
$929.23M
2020-07-10
2020-07-14
DREYER SCOTT
EVP & Chief Commercial Officer
F - Tax
Common Stock
-594
$17.00
-10,098
1
$929.23M
2020-07-01
2020-07-02
CIAFFONI JOSEPH
President and CEO
F - Tax
Common Stock
-1,394
$17.00
-23,698
1
$929.23M
2020-06-02
2020-06-02
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-5,861
$20.00
-117K
2
$929.23M
2020-06-01
2020-06-02
CIAFFONI JOSEPH
President and CEO
S - Sale
Common Stock
-70,676
$22.00
-1.55M
2
$929.23M
2020-06-01
2020-06-02
CIAFFONI JOSEPH
President and CEO
M - Exercise
Stock Option (Right to Purchase)
-64,820
$0.00
1
$929.23M
2020-06-01
2020-06-02
CIAFFONI JOSEPH
President and CEO
F - Tax
Common Stock
-4,672
$21.00
-98,112
1
$929.23M
2020-06-01
2020-06-02
CIAFFONI JOSEPH
President and CEO
M - Exercise
Common Stock
64,820
$8.00
519K
1
$929.23M
2020-05-20
2020-05-22
FREUND JOHN GORDON
A - Grant
Stock Option (Right to Purchase)
8,095
$0.00
1
$929.23M
2020-05-20
2020-05-22
HEFFERNAN MICHAEL THOMAS
A - Grant
Stock Option (Right to Purchase)
8,095
$0.00
1
$929.23M
2020-05-20
2020-05-22
SCHROEDER THEODORE
A - Grant
Stock Option (Right to Purchase)
8,095
$0.00
1
$929.23M
2020-05-18
2020-05-20
DREYER SCOTT
EVP & Chief Commercial Officer
M - Exercise
Stock Option (Right to Purchase)
-8,000
$0.00
1
$929.23M
2020-05-18
2020-05-20
DREYER SCOTT
EVP & Chief Commercial Officer
M - Exercise
Common Stock
8,000
$16.00
128K
1
$929.23M
2020-05-18
2020-05-20
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-8,000
$24.00
-192K
1
$929.23M
2020-05-13
2020-05-15
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-4,434
$23.00
-102K
1
$929.23M
2020-05-13
2020-05-15
FLEMING ALISON
Chief Technology Officer
S - Sale
Common Stock
-7,989
$22.00
-176K
2
$929.23M
2020-04-01
2020-04-03
MALAMUT RICHARD
EVP and Chief Medical Officer
F - Tax
Common Stock
-2,920
$15.00
-43,800
1
$929.23M
2020-03-16
2020-03-18
KUHLMANN SHIRLEY
EVP and General Counsel
F - Tax
Common Stock
-734
$15.00
-11,010
1
$929.23M
2020-02-10
2020-02-12
BRANNELLY PAUL
Executive Vice President & CFO
F - Tax
Common Stock
-4,025
$22.00
-88,550
1
$929.23M
2020-02-10
2020-02-12
CIAFFONI JOSEPH
President and CEO
F - Tax
Common Stock
-7,499
$22.00
-165K
1
$929.23M
2020-02-10
2020-02-12
DREYER SCOTT
EVP & Chief Commercial Officer
F - Tax
Common Stock
-1,966
$22.00
-43,252
1
$929.23M
2020-02-10
2020-02-12
FLEMING ALISON
Chief Technology Officer
F - Tax
Common Stock
-3,568
$22.00
-78,496
1
$929.23M
2020-02-10
2020-02-12
KUHLMANN SHIRLEY
EVP and General Counsel
F - Tax
Common Stock
-2,085
$22.00
-45,870
1
$929.23M
2020-02-05
2020-02-07
BRANNELLY PAUL
Executive Vice President & CFO
A - Grant
Stock Option (Right to Purchase)
31,250
$0.00
1
$929.23M
2020-02-05
2020-02-07
BRANNELLY PAUL
Executive Vice President & CFO
A - Grant
Common Stock
28,125
$0.00
1
$929.23M
2020-02-05
2020-02-07
CIAFFONI JOSEPH
President and CEO
A - Grant
Stock Option (Right to Purchase)
90,000
$0.00
1
$929.23M
2020-02-05
2020-02-07
DREYER SCOTT
EVP & Chief Commercial Officer
A - Grant
Stock Option (Right to Purchase)
21,250
$0.00
1
$929.23M
2020-02-05
2020-02-07
DREYER SCOTT
EVP & Chief Commercial Officer
A - Grant
Common Stock
19,125
$0.00
1
$929.23M
2020-02-05
2020-02-07
FLEMING ALISON
Chief Technology Officer
A - Grant
Stock Option (Right to Purchase)
25,000
$0.00
1
$929.23M
2020-02-05
2020-02-07
FLEMING ALISON
Chief Technology Officer
A - Grant
Common Stock
41,116
$0.00
2
$929.23M
2020-02-05
2020-02-07
KUHLMANN SHIRLEY
EVP and General Counsel
A - Grant
Stock Option (Right to Purchase)
27,500
$0.00
1
$929.23M
2020-02-05
2020-02-07
KUHLMANN SHIRLEY
EVP and General Counsel
A - Grant
Common Stock
24,750
$0.00
1
$929.23M
2020-02-05
2020-02-07
MALAMUT RICHARD
EVP and Chief Medical Officer
A - Grant
Stock Option (Right to Purchase)
22,500
$0.00
1
$929.23M
2020-02-05
2020-02-07
MALAMUT RICHARD
EVP and Chief Medical Officer
A - Grant
Common Stock
20,250
$0.00
1
$929.23M
2020-01-21
2020-01-22
BRANNELLY PAUL
Executive Vice President & CFO
F - Tax
Common Stock
-214
$22.00
-4,708
1
$929.23M
2020-01-21
2020-01-22
FLEMING ALISON
Chief Technology Officer
F - Tax
Common Stock
-214
$22.00
-4,708
1
$929.23M
2020-01-21
2020-01-22
HEFFERNAN MICHAEL THOMAS
M - Exercise
Stock Option (Right to Purchase)
-275K
$0.00
1
$929.23M
2020-01-14
2020-01-16
DREYER SCOTT
EVP & Chief Commercial Officer
S - Sale
Common Stock
-1,321
$24.00
-31,704
1
$929.23M
2020-01-10
2020-01-14
DREYER SCOTT
EVP & Chief Commercial Officer
F - Tax
Common Stock
-702
$23.00
-16,146
1
$929.23M
2020-01-02
2020-01-03
CIAFFONI JOSEPH
President and CEO
F - Tax
Common Stock
-1,091
$21.00
-22,911
1
$929.23M